You are visiting at a great time as spring will be arriving although also be prepared for cold weather. For me there are 3 parts to visiting Mendoza - the wines, the architecture of wineries and the restaurants. The views are a given as everything has the backdrop of the Andes.
In wine terms, I would visit Lujan de Cuyo, just 30 mins south of the city and Valle de Uco (up to 1 hour 30 from Mendoza depending where you are visiting). The Uco includes Tupungato, Gualtallary and Tunuyan (also home to Vista de Flores). You might consider staying in the city first and then changing to accommodation in the Uco to make the best of your time.
My recommendations would be Altavista, Mendel and Susan Balbo (just south in Agrelo) in Luyan. In Uco, I would visit Zuccardi and Salentien for the architecture and wines and Michel Roland’s estate (5 wineries) and Azul (small and rustic) for the wines.
In terms of restaurants, you tend to find international orientated food with an Argentine influence at the wineries whilst in Mendoza the emphasis is Argentine with an Italian influence. Most wineries provide a lunch paired with wines. If you do not fancy driving, we have used Trout and Wine a number of time for day excursions that include 3/4 wineries and lunch with paired wines - always very good and ask Charlie if he will do a discount.
In Lujan try the Bodega Vistalba Wine Bar (there is also a small restaurant on the stream running through the town called El Mercadito which is excellent - have lunch there with a Rose from the region - Calle Viamonte 4961, Chacras de Coria.
In Uco we really enjoy the lunches at Zuccardi. Whilst we stayed at the Vines Resort and Spa, which has a great location and views, Francis Mallmann’s Siete Fuegos was a bit of a disappointment - aimed at US and Brazilians in terms of both food and wine list prices (you should not expect to pay much more than the shop price for wines in Argentine restaurants.).
In Mendoza, we tend to go for the Italian influence - try Francesco Ristorante in Calle Chile or go to the central market for a slice of pizza and a beer. In Mendoza also visit the Cerro de la Gloria for views across the city and the Parc General St Martin.
If you are stopping off in Buenos Aires en route let me know.